Hydrochloride methanol → 4-(4-Fluoro-5-isoquinolyl)aminopiperidine hydrochloride

HRID 10529Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 10529
[F:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[NH:12][CH:13]2[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]2)[CH:5]=[N:4][CH:3]=1.[ClH:26].CO>>[ClH:26].[F:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[NH:12][CH:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)[CH:5]=[N:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 21893726Hydrochloride methanolHCID 219799884-(4-Fluoro-5-isoquinolyl)amino-1-(tert-butoxycarbonyl)piperidine

Produkt 1

HCID 219797714-(4-Fluoro-5-isoquinolyl)aminopiperidine hydrochloride

Versuchsvorschrift

According to the method of Example 1, Step C, deprotection was performed (50° C., 2 hours) by using Intermediate 72 (30.2 mg) and 10% hydrogen chloride/methanol solution (3 ml). The reaction mixture was cooled to room temperature, and then the solvent was evaporated under reduced pressure. The residue was added with methanol (1 ml) and diethyl ether (3 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (18.1 mg) as light yellow powdery solid.

Aufarbeitung

  1. custom(50° C., 2 hours)
  2. customthe solvent was evaporated under reduced pressure
  3. additionThe residue was added with methanol (1 ml) and diethyl ether (3 ml)
  4. customThe deposited precipitates
  5. filtrationwere collected by filtration
  6. washwashed with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-c17282f2eff94c059e2a09b237b7e77a
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07094789B2

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