HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1052924Generated: November 4, 2026
1-Hydroxybenzotriazole → HCID 72696793, compound
https://huagongshe.com/reaction/1052924
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 2-(Ethylsulfanyl)benzoic acid | HCID 425758 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 2-Amino-5-(trifluoromethyl)pyridine | HCID 735862 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 72696793 | HCID 72696793 | 36.8% |
Reaction Steps
A mixture of 0.81 g of 2-amino-5-trifluoromethylpyridine, 0.91 g of 2-ethylsulfanyl-benzoic acid, 1.15 g of EDCI hydrochloride, 0.06 g of HOBt and 10 mL of pyridine was stirred at 60° C. for 2 hours. A saturated aqueous sodium bicarbonate solution was added to the cooled reaction mixture, and the precipitated solid was taken by filtration and washed with acetonitrile to obtain 0.60 g of 2-ethylsulfanyl-N-(5-trifluoromethyl-pyridin-2-yl)-benzamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09392791B2 |
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| Source dataset | uspto-grants-2016_07 |
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| ORD ID | ord-79dbcce8bd21424a92314aa74c4c4e72 |
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| Source note | uspto-grants-2016_07 |
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