Sodium Thiosulfate → HCID 72944737, compound

Participants

Reaction Steps

0.82 g of m-chloroperbenzoic acid (purity of 68%) was added to a mixture of 0.63 g of 2-ethylsulfanyl-N-methyl-4-trifluoromethyl-N-(5-trifluoromethylsulfanyl-pyridin-2-yl)-benzamide and 10 mL of chloroform under ice cooling, and the mixture was stirred for 2 hours under ice cooling. A saturated aqueous sodium bicarbonate solution and a saturated aqueous sodium thiosulfate solution were added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting residue was applied to a silica gel column chromatography to obtain 0.62 g of 2-ethylsulfonyl-N-methyl-4-trifluoromethyl-N-(5-trifluoromethylsulfanyl-pyridin-2-yl)-benzamide (hereinafter, referred to as Compound of Present Invention 10) and 0.04 g of 2-ethylsulfonyl-N-methyl-4-trifluoromethyl-N-(5-trifluoromethylsulfinyl-pyridin-2-yl)-benzamide (hereinafter, referred to as Compound of Present Invention 11).

Provenance & Evidence