反应详情

A solution of (R)-naproxen (925 mg, 4.02 mmol) in 3 mL of methanol was added to a solution of (+)-tramadol (530 mg, 2.01 mmol) in 1 mL of methanol. The mixture was stirred for 10 minutes and about half of the solvent was evaporated. The resulting solution was left standing at room temperature and after 24 hours a solid had formed. The solid was filtered off, the filtrate was washed with 2 mL of methanol and dried under vacuum (10 mm Hg) for 4 hours to give the methanol solvate of the 1:2 co-crystal of (+)-tramadol-(R)-naproxen as crystalline white needles (610 mg, 42%).

1. customwas evaporated
2. waitThe resulting solution was left
3. waitstanding at room temperature and after 24 hours
4. customa solid had formed
5. filtrationThe solid was filtered off
6. washthe filtrate was washed with 2 mL of methanol
7. customdried under vacuum (10 mm Hg) for 4 hours