Pyridine → HCID 117668198, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-(3,5-dimethylisoxazol-4-yl)-3-hydroxy-3-(thiophen-3-yl)indolin-2-one (500 mg, 1.53 mmol) in CH2Cl2 (75.0 mL) was added pyridine (1.21 g, 15.3 mmol) followed by SOCl2 (728 mg, 6.12 mmol) at 0° C. The reaction mixture was stirred at 0° C. for 2 h and the mixture was evaporated in vacuum to give crude product, which was used for the next step without further purification.

Provenance & Evidence