HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Pentanamine → 4-(1-Ethyl-propylamino)-8-methoxy-quinoline-3-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Pentanamine | HCID 12019 | — |
| Reactant | 3-Quinolinecarboxylic acid, 4-chloro-8-methoxy-, ethyl ester | HCID 304557 | — |
| Product | 4-(1-Ethyl-propylamino)-8-methoxy-quinoline-3-carboxylic acid ethyl ester | HCID 67250481 | — |
Reaction Steps
4-Chloro-8-methoxy-quinoline-3-carboxylic acid ethyl ester (250 mg, 0.94 mmol) was treated with 1-ethyl-propylamine following general procedure B to afford 4-(1-ethyl-propylamino)-8-methoxy-quinoline-3-carboxylic acid ethyl ester (240 mg). Thus obtained amino-ester was hydrolyzed to the corresponding acid in quantitative yield using general procedure D and then transformed into the corresponding ethylamide (160 mg) following general procedure E.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09393245B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-043a835e708e437e94eeb713bc6ef055 |
| Source note | uspto-grants-2016_07 |