HCID 123988195, compound → HCID 90228697, compound

HRID 1053473Notes

Reaction equation

HRID 1053473 reaction equation
C([O:8][N:9]1[C:15](=[O:16])[N:14]2[CH2:17][C@H:10]1[CH2:11][CH2:12][C@H:13]2[C:18]([NH:20][NH:21][C:22](=[O:33])[C@H:23]([NH:25][C:26](=[O:32])[O:27][C:28]([CH3:31])([CH3:30])[CH3:29])[CH3:24])=[O:19])C1C=CC=CC=1>CO.[Pd]>[OH:8][N:9]1[C:15](=[O:16])[N:14]2[CH2:17][C@H:10]1[CH2:11][CH2:12][C@H:13]2[C:18]([NH:20][NH:21][C:22](=[O:33])[C@H:23]([NH:25][C:26](=[O:32])[O:27][C:28]([CH3:30])([CH3:29])[CH3:31])[CH3:24])=[O:19]

Participants

4

Reactant 1

HCID 123988195HCID 123988195, compound

Product 1

HCID 90228697HCID 90228697, compoundYield 100.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of compound 275 (400 mg, 0.86 mmol) in 30 mL of MeOH was added 0.8 g of Pd/C (10%, wet). The mixture was hydrogenated at room temperature for 2 h. The catalyst was removed by filtration through a celite pad. The filtrate was concentrated to afford compound 276 as a colorless gum (320 mg, 99%).

Workup

  1. customThe catalyst was removed by filtration through a celite pad
  2. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-75a96a71d17345aaaea80f667f90b6cf
Source dataset
uspto-grants-2016_07
Patent number
US09393239B2

Reaction notes

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