HCID 131731727, compound → HCID 90228699, compound

HRID 1053478Notes

Reaction equation

HRID 1053478 reaction equation
C([O:8][N:9]1[C:15](=[O:16])[N:14]2[CH2:17][C@H:10]1[CH2:11][CH2:12][C@H:13]2[C:18]([NH:20][NH:21][C:22]([C@@H:24]1[CH2:28][CH2:27][CH2:26][C@H:25]1[NH:29][C:30](=[O:36])[O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:23])=[O:19])C1C=CC=CC=1>CO.[Pd]>[OH:8][N:9]1[C:15](=[O:16])[N:14]2[CH2:17][C@H:10]1[CH2:11][CH2:12][C@H:13]2[C:18]([NH:20][NH:21][C:22]([C@@H:24]1[CH2:28][CH2:27][CH2:26][C@H:25]1[NH:29][C:30](=[O:36])[O:31][C:32]([CH3:34])([CH3:33])[CH3:35])=[O:23])=[O:19]

Participants

4

Reactant 1

HCID 131731727HCID 131731727, compound

Product 1

HCID 90228699HCID 90228699, compoundYield 83%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of compound 286 (0.22 g, 0.44 mmol) in 10 mL of CH3OH was added 0.1 g of Pd—C (10%, wet). The mixture was hydrogenated at room temperature for 16 h. The catalyst was removed by filtration through a pad of celite. The filtrate was concentrated to afford compound 287 as a solid (0.15 g, 83%).

Workup

  1. customThe catalyst was removed by filtration through a pad of celite
  2. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-a880250bfd33472cb5c975bd517a73af
Source dataset
uspto-grants-2016_07
Patent number
US09393239B2

Reaction notes

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