HCID 71736092, compound → HCID 71736093, compound

Participants

Reaction Steps

Compound 27 (60 mg, 0.13 mmol) was refluxed in concentrated hydrochloric acid for 2 hours. The reaction was concentrated, quenched with 50 mL of water, and neutralized with ammonium hydroxide to pH 7. The mixture was then extracted with EtOAc and the combined organic layer was washed with water, then brine, and dried over Na2SO4. The solvent was evaporated to yield the compound 28 (50 mg, 0.11 mmol, 85% yield). 1H NMR (CDCl3, 400 MHz) δ12.00 (bs, 1H), 8.92 (bs, 2H), 6.98 (d, J=8.0 Hz, 2H), 6.66-6.77 (m, 10H), 3.99-5.05 (m, 4H), 3.72 (t, J=5.6 Hz, 4H), 2.44 (t, J=7.2 Hz, 2H), 2.17 (t, J=7.2 Hz, 2H), 1.72 (q, J=7.2, 7.6 Hz, 2H); HRMS (ESI, positive) m/z calcd. for C26H30NO6 [M+H]+: 452.2073, found: 452.2007.

Provenance & Evidence