Lithium Hydroxide → HCID 178524949, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of product (1-A) (1.34 g, 3.8 mmol) in THF (30 mL) was added drop-wise a solution of LiOH (0.24 g, 10 mmol) in H2O (30 mL) at 0° C. The reaction mixture was stirred at 50° C. for about 2 h. After cooling, ethyl acetate (20 mL) and H2O (20 mL) were added to the solution. The aqueous layer was separated and acidified with citric acid (to pH=5) and extracted with ethyl acetate (50 mL×3). The combined organic phases were dried over Na2SO4 and concentrated to give crude product (2-A) (1.4 g, 100%) as a light yellow solid. LC-MS (M+H)+=324.

Provenance & Evidence