Trifluoroacetic acid → HCID 178485597, compound

Participants

Reaction Steps

To a solution of product (3-B) (17.1 g, 0.1 mol) in THF (100 mL) was added drop-wise a solution of TFA (57 g, 0.5 mol) in H2O (100 mL) at rt. The reaction mixture was stirred overnight at rt. The yellow precipitate was filtered, washed with H2O, and dried in air to give crude product (3-C) (12.5 g, 82%, for two steps) as a light yellow solid. 1H NMR (300 MHz, d-DMSO): δ 13.93 (br, 1H), 10.33 (br, 1H), 8.52 (br, 1H), 8.44 (s, 1H), 2.79 (d, 3H). LC-MS (M+H)+=154.

Provenance & Evidence