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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1053674Generated: November 1, 2026

2-Trifluoromethylphenol → (R)-4-(3-(Trifluoromethyl)phenyl)butan-2-amine hydrochloride

https://huagongshe.com/reaction/1053674

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-TrifluoromethylphenolHCID 67958—
Reactant(R)-4-(3,4-dichlorophenyl)butan-2-amine hydrochlorideHCID 86731090—
Product(R)-4-(3-(Trifluoromethyl)phenyl)butan-2-amine hydrochlorideHCID 8985273788%

Reaction Steps

Intermediate 5 (55 mg, 0.25 mmol, 88% yield) was prepared as a white powder following the procedure described for Intermediate 4 by replacing 2,6-dichlorophenol with 2-trifluromethylphenol. LC-MS (ESI) 218.1 (M+H), RT=1.60 min (Method B).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09394260B2
Source datasetuspto-grants-2016_07
ORD IDord-904d5702955749afa1987a59c355dc2b
Source noteuspto-grants-2016_07