Water → HCID 89862965, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2-(trifluoromethyl)phenol (250 mg, 1.54 mmol), tetrabutyl ammonium iodide (114 mg, 1.31 mmol) and 2-(3-bromopropyl)isoindoline-1,3-dione (455 mg, 1.70 mmol) was stirred in THF (10 mL) at rt. Cs2CO3 (904 mg, 2.78 mmol) was added. The resulting mixture was stirred at 60° C. for 16 h. H2O was added to the reaction mixture and the aqueous layer was extracted with EtOAc. The organic layer was dried over MgSO4, filtered and concentrated. The residue was purified by triturating with Et2O to yield Intermediate 6A (0.50 g, 1.4 mmol, 93% yield) as a white powder. LC-MS (ESI) 350 (M+H), RT=3.41 min (Method B).

Provenance & Evidence