tert-Butylsulfinamide, (R)-(+)- → HCID 178465718, compound

Participants

Role	Name	HCID	Charge
Reactant	tert-Butylsulfinamide, (R)-(+)-	HCID 10964479	—
Reactant	1-(3-Bromo-2-methylphenyl)ethanone	HCID 20480131	—
Catalyst	HCID 178477244	HCID 178477244	—
Solvent	Tetrahydrofuran	HCID 8028	—
Product	HCID 178465718	HCID 178465718	—

Reaction Conditions

Temperature	75 °C

Reaction Steps

To a stirring solution of (R)-2-methylpropane-2-sulfinamide (326 mg, 2.69 mmol) and Intermediate 12A (600 mg, 2.82 mmol) in THF (2 mL) at rt was added tetraethoxytitanium (1.06 mL, 5.12 mmol). The reaction mixture was heated at 75° C. for 16 h. The reaction mixture was cooled and used directly in the next step. LCMS=2.12 min [M+1]=318.0 (Method B).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09394260B2
Source dataset	uspto-grants-2016_07
ORD ID	ord-d892c17472244c0eb000762b3c79055c
Source note	uspto-grants-2016_07