HRID1053775

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCOc1ccc(Cc2nc(-c3cccc4c3CC[C@@H]4N(CC(=O)N(C)C)C(=O)OC(C)(C)C)no2)cc1OCC

HCID67197972

未命名化合物

结构：OCCN[C@@H]1CCc2c(-c3noc(-c4cc(-c5ccccc5)c(C(F)(F)F)s4)n3)cccc21

HCID67319515

未命名化合物

PRODUCTS

生成物

结构：CCOc1ccc(Cc2nc(-c3cccc4c3CC[C@@H]4NCC(=O)N(C)C)no2)cc1OCC

HCID67198667

未命名化合物

PROCEDURE

实验过程

(S)-2-((4-(5-(3,4-diethoxybenzyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)amino)-N,N-dimethylacetamide 66 was prepared analogously to compound 67 from (S)-tert-butyl (4-(5-(3,4-diethoxybenzyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)(2-(dimethylamino)-2-oxoethyl)carbamate INT-64.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-47c6cafa215346a7be2b4b6bc8a2549b
来源数据集: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09394264B2
来源说明: uspto-grants-2016_07

反应 SMILES

C1(C2C=C(C3ON=C(C4C=CC=C5C=4CC[C@H]5NCCO)N=3)SC=2C(F)(F)F)C=CC=CC=1.[CH2:34]([O:36][C:37]1[CH:38]=[C:39]([CH:69]=[CH:70][C:71]=1[O:72][CH2:73][CH3:74])[CH2:40][C:41]1[O:45][N:44]=[C:43]([C:46]2[CH:54]=[CH:53][CH:52]=[C:51]3[C:47]=2[CH2:48][CH2:49][C@@H:50]3[N:55]([CH2:63][C:64]([N:66]([CH3:68])[CH3:67])=[O:65])C(=O)OC(C)(C)C)[N:42]=1)[CH3:35]>>[CH2:34]([O:36][C:37]1[CH:38]=[C:39]([CH:69]=[CH:70][C:71]=1[O:72][CH2:73][CH3:74])[CH2:40][C:41]1[O:45][N:44]=[C:43]([C:46]2[CH:54]=[CH:53][CH:52]=[C:51]3[C:47]=2[CH2:48][CH2:49][C@@H:50]3[NH:55][CH2:63][C:64]([N:66]([CH3:67])[CH3:68])=[O:65])[N:42]=1)[CH3:35]