N-Iodosuccinimide → HCID 131736288, compound

Participants

Reaction Steps

Cp2ZrHCl (628 mg, 2.5 mmol) was added to a solution of tert-butyl((1-(3-chlorobenzo[b]thiophen-2-yl)but-3-yn-2-yl)oxy)dimethylsilane (565 mg, 1.61 mmol) in CH2Cl2 (11 mL). The reaction was stirred for 1 h and then N-iodosuccinimide (585 mg, 2.6 mmol) was added. After 30 minutes, 30 mL saturated NaHCO3 solution was added and the resulting mixture was extracted with CH2Cl2 (3×30 mL). The combined organic solution was dried (Na2SO4), filtered and evaporated. Purification by flash chromatography (ethyl acetate/hexanes) gave the title compound (669 mg, 87%).

Provenance & Evidence