2-methyl-2-propanyl 4-[({(2S,4S)-4-[4-(methylsulfonyl)-1-piperazinyl]-2-pyrrolidinyl}carbonyl)amino]benzoate → HCID 178454283, compound

HRID 1053817Notes

Reaction equation

HRID 1053817 reaction equation
[CH3:1][S:2]([N:5]1[CH2:10][CH2:9][N:8]([C@@H:11]2[CH2:15][NH:14][C@H:13]([C:16]([NH:18][C:19]3[CH:31]=[CH:30][C:22]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])=[CH:21][CH:20]=3)=[O:17])[CH2:12]2)[CH2:7][CH2:6]1)(=[O:4])=[O:3].[CH3:32][C:33]([O:36][C:37]([NH:39][C:40](=[N:51][C:52]([O:54][C:55]([CH3:58])([CH3:57])[CH3:56])=[O:53])[NH:41][C:42]1[CH:50]=[CH:49][C:45]([C:46](O)=[O:47])=[CH:44][CH:43]=1)=[O:38])([CH3:35])[CH3:34]>>[CH3:58][C:55]([O:54][C:52]([NH:51][C:40](=[N:39][C:37]([O:36][C:33]([CH3:35])([CH3:34])[CH3:32])=[O:38])[NH:41][C:42]1[CH:50]=[CH:49][C:45]([C:46]([N:14]2[CH2:15][C@@H:11]([N:8]3[CH2:9][CH2:10][N:5]([S:2]([CH3:1])(=[O:4])=[O:3])[CH2:6][CH2:7]3)[CH2:12][C@H:13]2[C:16]([NH:18][C:19]2[CH:31]=[CH:30][C:22]([C:23]([O:25][C:26]([CH3:28])([CH3:27])[CH3:29])=[O:24])=[CH:21][CH:20]=2)=[O:17])=[O:47])=[CH:44][CH:43]=1)=[O:53])([CH3:56])[CH3:57]

Participants

3

Reactant 2

HCID 1181076652-methyl-2-propanyl 4-[({(2S,4S)-4-[4-(methylsulfonyl)-1-piperazinyl]-2-pyrrolidinyl}carbonyl)amino]benzoateHCID 178454296HCID 178454296, compound

Product 1

HCID 178454283HCID 178454283, compound

Procedure

Following the procedure described in Example 8, the compound prepared in Example 6 was treated with the compound prepared in Example 10 to give the title compound as a white solid.

Sources & evidence

ORD record
ord-57faa79c712243b3b84ff822e7a56afa
Source dataset
uspto-grants-2016_07
Patent number
US09394250B2

Reaction notes

Loading…