反应详情

To a solution of the compound prepared in Example 17 (0.20 g, 0.72 mmol) in methanol (10 mL) was added 1 M aqueous sodium hydroxide (5 mL). The reaction was stirred at room temperature for 1 h. The mixture was concentrated and the resulting aqueous residue was diluted with ethyl acetate. The aqueous layer was acidified with 1 M hydrochloric acid to pH 4-5 and extracted with ethyl acetate (2×20 mL). The combined organic extracts were dried and concentrated to give the title compound (0.208 g, >99%) as a white solid.

1. concentrationThe mixture was concentrated
2. additionthe resulting aqueous residue was diluted with ethyl acetate
3. extractionextracted with ethyl acetate (2×20 mL)
4. customThe combined organic extracts were dried
5. concentrationconcentrated