2-methyl-2-propanyl 4-[({(2S,4S)-4-[4-(methylsulfonyl)-1-piperazinyl]-2-pyrrolidinyl}carbonyl)amino]benzoate → tert-butyl 4-[[(2S,4S)-1-[4-[N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]benzoyl]-4-(4-methylsulfonylpiperazin-1-yl)pyrrolidine-2-carbonyl]amino]benzoate

Participants

Role	Name	HCID	Charge
Reactant	2-methyl-2-propanyl 4-[({(2S,4S)-4-[4-(methylsulfonyl)-1-piperazinyl]-2-pyrrolidinyl}carbonyl)amino]benzoate	HCID 118107665	—
Reactant	HCID 135741236	HCID 135741236	—
Product	tert-butyl 4-[[(2S,4S)-1-[4-[N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]benzoyl]-4-(4-methylsulfonylpiperazin-1-yl)pyrrolidine-2-carbonyl]amino]benzoate	HCID 140675252	—

Reaction Steps

Following the procedure described in Example 8, the compound prepared in Example 6 was treated with the compound prepared in Example 18 to give the title compound as a white solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09394250B2
Source dataset	uspto-grants-2016_07
ORD ID	ord-793803ff8a284096a3bd7de4564d5473
Source note	uspto-grants-2016_07