Triethylamine → benzyl 4-(N,N'-bis{[(2-methyl-2-propanyl)oxy]carbonyl}carbamimidoyl)-1-piperazinecarboxylate

Participants

Role	Name	HCID	Charge
Reactant	Triethylamine	HCID 8471	—
Reactant	Benzyl piperazine-1-carboxylate	HCID 643495	—
Reactant	N,N'-Bis(tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine	HCID 4428040	—
Solvent	Methanol	HCID 887	—
Product	benzyl 4-(N,N'-bis{[(2-methyl-2-propanyl)oxy]carbonyl}carbamimidoyl)-1-piperazinecarboxylate	HCID 131736303	50.3%

Reaction Steps

Following the procedure described in Example 7, the reaction of N,N′-bis{[(2-methyl-2-propanyl)oxy]carbonyl}-1H-pyrazole-1-carboximidamide (0.25 g, 1.1 mmol), triethylamine (0.5 mL, 3.4 mmol) and benzyl piperazine-1-carboxylate (0.422 g, 1.36 mmol) in methanol (10 mL) gave the title compound (0.256 g, 50%) as a colorless liquid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09394250B2
Source dataset	uspto-grants-2016_07
ORD ID	ord-a2f73f0610154e7193e75d0596ef9244
Source note	uspto-grants-2016_07