HRID1053840

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)Nc1ccc(-c2cnc([C@@H]3C[C@H](C4CCN(S(C)(=O)=O)CC4)CN3)[nH]2)cc1.Cl

HCID131736307

未命名化合物

结构：CC(C)(C)OC(=O)N=C(NC(=O)OC(C)(C)C)Nc1ccc(C(=O)O)cc1

HCID178454296

未命名化合物

PRODUCTS

生成物

结构：COC(=O)Nc1ccc(-c2cnc([C@H]3C[C@@H](C4CCN(S(C)(=O)=O)CC4)CN3C(=O)c3ccc(NC(=NC(=O)OC(C)(C)C)NC(=O)OC(C)(C)C)cc3)[nH]2)cc1

HCID178501951

未命名化合物

PROCEDURE

实验过程

The compound prepared in Example 66 was treated with the compound prepared in Example 10 following the procedure described in Example 8 to give the title compound as a light brown solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1c3fd48cc95349d6a0c3c7c81f858a28
来源数据集: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09394250B2
来源说明: uspto-grants-2016_07

反应 SMILES

Cl.[CH3:2][S:3]([N:6]1[CH2:11][CH2:10][CH:9]([C@@H:12]2[CH2:16][NH:15][C@H:14]([C:17]3[NH:18][C:19]([C:22]4[CH:27]=[CH:26][C:25]([NH:28][C:29](=[O:32])[O:30][CH3:31])=[CH:24][CH:23]=4)=[CH:20][N:21]=3)[CH2:13]2)[CH2:8][CH2:7]1)(=[O:5])=[O:4].[CH3:33][C:34]([O:37][C:38]([NH:40][C:41](=[N:52][C:53]([O:55][C:56]([CH3:59])([CH3:58])[CH3:57])=[O:54])[NH:42][C:43]1[CH:51]=[CH:50][C:46]([C:47](O)=[O:48])=[CH:45][CH:44]=1)=[O:39])([CH3:36])[CH3:35]>>[CH3:59][C:56]([O:55][C:53]([NH:52][C:41](=[N:40][C:38]([O:37][C:34]([CH3:36])([CH3:35])[CH3:33])=[O:39])[NH:42][C:43]1[CH:51]=[CH:50][C:46]([C:47]([N:15]2[CH2:16][C@H:12]([CH:9]3[CH2:8][CH2:7][N:6]([S:3]([CH3:2])(=[O:4])=[O:5])[CH2:11][CH2:10]3)[CH2:13][C@@H:14]2[C:17]2[NH:18][C:19]([C:22]3[CH:23]=[CH:24][C:25]([NH:28][C:29](=[O:32])[O:30][CH3:31])=[CH:26][CH:27]=3)=[CH:20][N:21]=2)=[O:48])=[CH:45][CH:44]=1)=[O:54])([CH3:57])[CH3:58]