HCID 178454296, compound → HCID 178501957, compound

HRID 1053841Notes

Reaction equation

Cl.[Cl:2][C:3]1[N:4]=[C:5]([C@@H:19]2[CH2:23][C@H:22]([CH:24]3[CH2:29][CH2:28][N:27]([S:30]([CH3:33])(=[O:32])=[O:31])[CH2:26][CH2:25]3)[CH2:21][NH:20]2)[NH:6][C:7]=1[C:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15](=[O:18])[O:16][CH3:17])=[CH:10][CH:9]=1.[CH3:34][C:35]([O:38][C:39]([NH:41][C:42](=[N:53][C:54]([O:56][C:57]([CH3:60])([CH3:59])[CH3:58])=[O:55])[NH:43][C:44]1[CH:52]=[CH:51][C:47]([C:48](O)=[O:49])=[CH:46][CH:45]=1)=[O:40])([CH3:37])[CH3:36]>>[CH3:60][C:57]([O:56][C:54]([NH:53][C:42](=[N:41][C:39]([O:38][C:35]([CH3:37])([CH3:36])[CH3:34])=[O:40])[NH:43][C:44]1[CH:52]=[CH:51][C:47]([C:48]([N:20]2[CH2:21][C@H:22]([CH:24]3[CH2:29][CH2:28][N:27]([S:30]([CH3:33])(=[O:32])=[O:31])[CH2:26][CH2:25]3)[CH2:23][C@@H:19]2[C:5]2[NH:6][C:7]([C:8]3[CH:13]=[CH:12][C:11]([NH:14][C:15](=[O:18])[O:16][CH3:17])=[CH:10][CH:9]=3)=[C:3]([Cl:2])[N:4]=2)=[O:49])=[CH:46][CH:45]=1)=[O:55])([CH3:58])[CH3:59]

Participants

Reactant 2

HCID 178454296HCID 178454296, compound

HCID 178501961methyl [4-(4-chloro-2-{(2S,4R)-4-[1-(methylsulfonyl)-4-piperidinyl]-2-pyrrolidinyl}-1H-imidazol-5-yl)phenyl]carbamate hydrochloride

Product 1

HCID 178501957HCID 178501957, compound

Procedure

The compound prepared in Example 67 was treated with the compound prepared in Example 10 following the procedure described in Example 8 to give the title compound as a light brown solid.

Sources & evidence

ORD record: ord-5d83b08c49f3486983221d0e3b08ea2b
Source dataset: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09394250B2

Reaction notes

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