methyl [4-(2-{(2S,4R)-4-[1-(methylsulfonyl)-4-piperidinyl]-2-pyrrolidinyl}-1H-imidazol-5-yl)phenyl]carbamate hydrochloride → HCID 178501952, compound

HRID 1053843Notes

Reaction equation

HRID 1053843 reaction equation
Cl.[CH3:2][S:3]([N:6]1[CH2:11][CH2:10][CH:9]([C@@H:12]2[CH2:16][NH:15][C@H:14]([C:17]3[NH:18][C:19]([C:22]4[CH:27]=[CH:26][C:25]([NH:28][C:29](=[O:32])[O:30][CH3:31])=[CH:24][CH:23]=4)=[CH:20][N:21]=3)[CH2:13]2)[CH2:8][CH2:7]1)(=[O:5])=[O:4].[CH3:33][C:34]([O:37][C:38]([NH:40][C@H:41]([C@H:43]1[CH2:48][CH2:47][C@H:46]([C:49](O)=[O:50])[CH2:45][CH2:44]1)[CH3:42])=[O:39])([CH3:36])[CH3:35]>>[CH3:31][O:30][C:29]([NH:28][C:25]1[CH:24]=[CH:23][C:22]([C:19]2[NH:18][C:17]([C@@H:14]3[CH2:13][C@H:12]([CH:9]4[CH2:8][CH2:7][N:6]([S:3]([CH3:2])(=[O:4])=[O:5])[CH2:11][CH2:10]4)[CH2:16][N:15]3[C:49]([C@H:46]3[CH2:45][CH2:44][C@H:43]([C@@H:41]([NH:40][C:38](=[O:39])[O:37][C:34]([CH3:36])([CH3:35])[CH3:33])[CH3:42])[CH2:48][CH2:47]3)=[O:50])=[N:21][CH:20]=2)=[CH:27][CH:26]=1)=[O:32]

Participants

3

Reactant 2

HCID 131736307methyl [4-(2-{(2S,4R)-4-[1-(methylsulfonyl)-4-piperidinyl]-2-pyrrolidinyl}-1H-imidazol-5-yl)phenyl]carbamate hydrochlorideHCID 178462198HCID 178462198, compound

Product 1

HCID 178501952HCID 178501952, compound

Procedure

Following the procedure described in Example 8, the compound prepared in Example 66 was treated with trans-4-[(1S)-1-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)ethyl]cyclohexanecarboxylic acid to give the title compound as a light brown solid.

Sources & evidence

ORD record
ord-950b3569a5544513a3c9f6cde5ea3c27
Source dataset
uspto-grants-2016_07
Patent number
US09394250B2

Reaction notes

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