HRID1053843

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)Nc1ccc(-c2cnc([C@@H]3C[C@H](C4CCN(S(C)(=O)=O)CC4)CN3)[nH]2)cc1.Cl

HCID131736307

未命名化合物

结构：C[C@H](NC(=O)OC(C)(C)C)[C@H]1CC[C@H](C(=O)O)CC1

HCID178462198

未命名化合物

PRODUCTS

生成物

结构：COC(=O)Nc1ccc(-c2cnc([C@@H]3C[C@H](C4CCN(S(C)(=O)=O)CC4)CN3C(=O)[C@H]3CC[C@H]([C@H](C)NC(=O)OC(C)(C)C)CC3)[nH]2)cc1

HCID178501952

未命名化合物

PROCEDURE

实验过程

Following the procedure described in Example 8, the compound prepared in Example 66 was treated with trans-4-[(1S)-1-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)ethyl]cyclohexanecarboxylic acid to give the title compound as a light brown solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-950b3569a5544513a3c9f6cde5ea3c27
来源数据集: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09394250B2
来源说明: uspto-grants-2016_07

反应 SMILES

Cl.[CH3:2][S:3]([N:6]1[CH2:11][CH2:10][CH:9]([C@@H:12]2[CH2:16][NH:15][C@H:14]([C:17]3[NH:18][C:19]([C:22]4[CH:27]=[CH:26][C:25]([NH:28][C:29](=[O:32])[O:30][CH3:31])=[CH:24][CH:23]=4)=[CH:20][N:21]=3)[CH2:13]2)[CH2:8][CH2:7]1)(=[O:5])=[O:4].[CH3:33][C:34]([O:37][C:38]([NH:40][C@H:41]([C@H:43]1[CH2:48][CH2:47][C@H:46]([C:49](O)=[O:50])[CH2:45][CH2:44]1)[CH3:42])=[O:39])([CH3:36])[CH3:35]>>[CH3:31][O:30][C:29]([NH:28][C:25]1[CH:24]=[CH:23][C:22]([C:19]2[NH:18][C:17]([C@@H:14]3[CH2:13][C@H:12]([CH:9]4[CH2:8][CH2:7][N:6]([S:3]([CH3:2])(=[O:4])=[O:5])[CH2:11][CH2:10]4)[CH2:16][N:15]3[C:49]([C@H:46]3[CH2:45][CH2:44][C@H:43]([C@@H:41]([NH:40][C:38](=[O:39])[O:37][C:34]([CH3:36])([CH3:35])[CH3:33])[CH3:42])[CH2:48][CH2:47]3)=[O:50])=[N:21][CH:20]=2)=[CH:27][CH:26]=1)=[O:32]