Potassium Hydroxide → HCID 68006783, compound

Participants

Reaction Steps

A mixture of Example 7K (475 mg, 0.847 mmol), hydroxylamine hydrochloride (353 mg, 5.08 mmol) and KOH (143 mg, 2.54 mmol) in ethanol (6 mL) and water (2 mL) was stirred at 65° C. for 48 hours. The mixture was concentrated in vacuo. The residue was diluted with ethyl acetate (20 mL) and washed with brine (6 mL×2). The organic layer was dried over Na2SO4, filtered and concentrated. The residue was used directly in the next step without further purification. LC/MS (ESI) m/z 483 (M+H)+.

Provenance & Evidence