Methanol → HCID 86685695, compound

HRID 1053994Notes

Reaction equation

[C:1]([C:3]1[CH:4]=[CH:5][C:6]([O:21][CH2:22][CH:23]([CH2:26][CH3:27])[CH2:24][CH3:25])=[C:7]([CH:20]=1)[CH2:8][N:9]1[C:13]([CH3:14])=[CH:12][C:11]([CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[N:10]1)#N.[OH-:28].[Na+].C[OH:31]>>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([O:21][CH2:22][CH:23]([CH2:26][CH3:27])[CH2:24][CH3:25])=[C:7]([CH:20]=1)[CH2:8][N:9]1[C:13]([CH3:14])=[CH:12][C:11]([CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[N:10]1)([OH:31])=[O:28]

Participants

Reactant 3

HCID 887Methanol

HCID 14798Sodium Hydroxide

HCID 86685696HCID 86685696, compound

Product 1

HCID 86685695HCID 86685695, compound

Conditions

Temperature: 140 °C

Procedure

The title compound was prepared from 1 3-{1-[5-Cyano-2-(2-ethyl-butoxy)-benzyl]-5-methyl-1H-pyrazol-3-yl}-propionic acid following the methods described in example 64, but replacing LiOH with NaOH and adding MeOH as co-solvent while heating in a microwave reactor at 140° C. in a microwave reactor for 30 min.

Sources & evidence

ORD record: ord-6a83b8196fc54b488d11fabbeb7714e0
Source dataset: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09394284B2

Reaction notes

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