HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → N-(Piperidin-3-yl)isoquinolin-5-amine--hydrogen chloride (1/1)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Hydrogen chloride-ethyl acetate | HCID 21866389 | — |
| Reactant | HCID 21979767 | HCID 21979767 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | N-(Piperidin-3-yl)isoquinolin-5-amine--hydrogen chloride (1/1) | HCID 69523874 | 100% |
Reaction Steps
To a solution of 3-(isoquinolin-5-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (80 g, 0.244 mol) in EtOAc (1000 mL) was added HCl-EtOAc (1000 mL) at room temperature. The mixture was stirred at room temperature for 2.5 hours. TLC (DCM:MeOH=10:1) showed complete conversion. The solid was collected by filtration and dried under vacuum to give the title compound (66 g, 100%) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09394286B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-1ec07b4c8c084efa903e3b51b1093201 |
| Source note | uspto-grants-2016_07 |