tert-Butyl (1R*,4R*)-4-(3-nitrobenzylamino)cyclohexylcarbamate → HCID 62314401, compound

Participants

Reaction Conditions

Reaction Steps

Tert-butyl N-(4-[(3-nitrobenzyl)amino]cyclohexyl)carbamate (30.0 g, 86.1 mmol, 1.0 eq) was dissolved in 300 mL of TFA:DCM (1:10) and the resulting solution was stirred at 30° C. overnight. The reaction mixture was then concentrated under vacuum to provide crude 1-N-(3-nitrobenzyl)cyclohexane-1,4-diamine (32 g, TFA salt) as a white solid.

Provenance & Evidence