HCID 10520795, compound → HCID 17885188, compound

HRID 1054028Notes

Reaction equation

[N+:1]([C:4]1[CH:5]=[C:6]([CH:22]=[CH:23][CH:24]=1)[CH2:7][N:8]1[CH2:13][CH2:12][CH:11]([NH:14]C(=O)OC(C)(C)C)[CH2:10][CH2:9]1)([O-:3])=[O:2]>C(O)(C(F)(F)F)=O.C(Cl)Cl>[N+:1]([C:4]1[CH:5]=[C:6]([CH:22]=[CH:23][CH:24]=1)[CH2:7][N:8]1[CH2:9][CH2:10][CH:11]([NH2:14])[CH2:12][CH2:13]1)([O-:3])=[O:2]

Participants

Conditions

Temperature: 30 °C

Procedure

Tert-butyl N-{1-(3-nitrobenzyl)piperidin-4-yl}carbamate (30.0 g, 89.5 mmol, 1.0 eq)) was dissolved in 300 mL of TFA:DCM (1:10) and the resulting solution stirred at 30° C. overnight. The reaction mixture was then concentrated under vacuum to provide crude 1-(3-nitrobenzyl)piperidin-4-amine (33 g, TFA salt) as a white solid.

Workup

concentrationThe reaction mixture was then concentrated under vacuum

Sources & evidence

ORD record: ord-6efefdeb14474fe3ada12e5d81433b33
Source dataset: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09394286B2

Reaction notes

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