N-bromobutanimide → 2-Bromo-5-bromomethylpyridine

Participants

Reaction Steps

Synthesized from 2-bromo-5-methylpyridine (3.00 g, 17.40 mmol), NBS (3.41 g, 19.20 mmol) and DBPO (230 mg, 0.80 mmol) in carbon tetrachloride according to Method A. Yield: 2.56 g (59%); lachrymatory yellow needles; 1H NMR (CDCl3, 500 MHz): δH (ppm)=4.14 (s, 2H), 7.47 (d, J=8.2 Hz, 1H), 7.59 (d, J=8.2 Hz, 1H), 8.38 (s, 1H); MS (ESI): m/z=252.37 [M+H]+.

Provenance & Evidence