Benzo(B)Thiophene-2-Boronic Acid → HCID 70685192, compound

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Reaction Steps

Synthesized using benzo[b]thiophen-2-ylboronic acid (149 mg, 0.84 mmol) and 1a (100 mg, 0.42 mmol) according to Method C. Yellow solid. Yield: 46 mg, 0.16 mmol, 38%. 1H NMR (CDCl3, 500 MHz): δH (ppm): 5.17 (s, 2H), 6.93 (t, J=1.3 Hz, 1H), 7.35-7.38 (m, 2H), 7.46 (dd, J=8.2, 2.2 Hz, 1H), 7.60 (brs, 1H), 7.79 (d, J=8.2 Hz, 1H), 7.80-7.83 (m 1H), 7.84 (d, J=0.6 Hz, 1H), 7.86-7.88 (m, 1H), 8.52 (d, J=1.9 Hz, 1H); 13C NMR (CDCl3, 125 MHz): δC (ppm)=48.1, 119.0, 119.7, 121.7, 122.6, 124.2, 123.6, 125.3, 130.4, 130.6, 135.6, 137.3, 140.3, 140.8, 143.8, 148.5, 152.8; MS (ESI): m/z=292.04 [M+H]+.

Provenance & Evidence