N-bromobutanimide → 3-(Bromomethyl)-6-phenylpyridazine

HRID 1054111Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1054111
[CH3:1][C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:6][CH:7]=1.C1C(=O)N([Br:21])C(=O)C1>C(Cl)(Cl)(Cl)Cl>[Br:21][CH2:1][C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 67184N-bromobutanimideHCID 113787443-Methyl-6-phenylpyridazine

Produkt 1

HCID 667174453-(Bromomethyl)-6-phenylpyridazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 5943Carbon TetrachlorideLösungsmittel

Versuchsvorschrift

Synthesized using compound 65b (982 mg, 5.77 mmol), NBS (1.13 g, 6.35 mmol) and DBPO (70 mg, 0.29 mmol) in carbon tetrachloride according to Method A. Crude product was purified by flash chromatography on silica-gel using hexane/ethyl acetate (4:1) as eluent. Product was used directly in the next step without further characterization. Orange solid. Yield: 53 mg, 4%. (ESI): m/z=250.67 [M+H]+.

Aufarbeitung

  1. customSynthesized
  2. customCrude product was purified by flash chromatography on silica-gel

Quellen und Nachweise

ORD-Eintrag
ord-e12083880c59418886cef06b3e62e0f5
Quelldatensatz
uspto-grants-2016_07
Patentnummer
US09394290B2

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