Imidazole → HCID 57330084, compound

Participants

Reaction Steps

Synthesized using compound 71a (100 mg, 0.40 mmol), imidazole (109 mg, 1.60 mmol) and K2CO3 (276 mg, 2.00 mmol) in DMF according to Method B. Crude product was purified by flash chromatography on silica-gel using ethyl acetate as eluent. Light yellow solid. Yield: 69 mg, 73%. 1H NMR (CDCl3, 500 MHz): δH (ppm)=5.50 (s, 2H), 7.24 (t, J=1.3 Hz, 1H), 7.33 (t, J=1.1 Hz, 1H), 7.64-7.74 (m, 3H), 7.86 (s, 1H), 8.17-8.23 (m, 2H), 8.63 (d, J=1.3 Hz, 1H), 9.18 (d, J=1.6 Hz, 1H); 13C NMR (CDCl3, 125 MHz): δC (ppm)=50.0, 119.2, 126.9, 129.1, 130.2, 130.3, 135.7, 137.5, 141.5, 142.3, 152.3; (ESI): m/z=236.91 [M+H]+.

Provenance & Evidence