5-(Pyridin-4-yl)-3,4-dihydroisoquinoline → Tert-butyl 4-(3,4-dihydroisoquinolin-5-yl)-3-oxopiperazine-1-carboxylate

HRID 1054138Notes

Reaction equation

HRID 1054138 reaction equation
[CH:1]1[C:10]2[C:5](=[C:6]([N:11]3[CH2:16][CH2:15][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13][C:12]3=[O:24])[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1.N1C=CC(C2C=CC=C3C=2CCN=C3)=CC=1>>[CH:1]1[C:10]2[C:5](=[C:6]([N:11]3[CH2:16][CH2:15][N:14]([C:17]([O:19][C:20]([CH3:22])([CH3:21])[CH3:23])=[O:18])[CH2:13][C:12]3=[O:24])[CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][N:2]=1

Participants

3

Reactant 2

HCID 895000175-(Pyridin-4-yl)-3,4-dihydroisoquinolineHCID 131732696tert-Butyl 4-(isoquinolin-5-yl)-3-oxopiperazine-1-carboxylate

Product 1

HCID 89499964Tert-butyl 4-(3,4-dihydroisoquinolin-5-yl)-3-oxopiperazine-1-carboxylate

Procedure

Intermediate 18 was prepared from Intermediate 18A as described for Intermediate 17. MS (ESI) m/z: 330.1 (M+H)+.

Sources & evidence

ORD record
ord-d8d78aec264b4a719eb0358b3e0a6986
Source dataset
uspto-grants-2016_07
Patent number
US09394276B2

Reaction notes

Loading…