反应详情

温度

27.5 °C

In a four neck round bottom flask charged Isopropyl alcohol (135 ml), 4-(4-aminophenyl) morpholin-3-one (10 g), 2-[(2s)-oxiran-2yl methyl]-1H-isoindole-1,3(2H)dione ((11.6 g) and water (15 ml) at 25 to 30° C. Slowly heated the reaction mixture to reflux and maintained for 24 h at reflux temperature. Reaction mass is cooled to 25 to 30° C. after completion of the reaction. Reaction mass then maintained at 25 to 30° C. for 30 minutes. Finally obtained solid is filtered off and washed by isopropyl alcohol (25 ml)

1. temperatureSlowly heated the reaction mixture
2. temperatureto reflux
3. temperaturemaintained for 24 h
4. temperatureat reflux temperature
5. customReaction mass
6. customafter completion of the reaction
7. customReaction mass
8. temperaturethen maintained at 25 to 30° C. for 30 minutes
9. filtrationFinally obtained solid is filtered off
10. washwashed by isopropyl alcohol (25 ml)