HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1054147Generated: October 31, 2026
Formic Acid → N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)formamide
https://huagongshe.com/reaction/1054147
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | (S)-4-(4-(5-(aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one | HCID 11346837 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)formamide | HCID 90258317 | — |
Reaction Steps
In a four neck round bottom flask charged 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one free base (50 g) toluene (350 ml) and formic acid (21.63 g). Reaction mass then heated azeotropically to 110-120° C. employing dean-stark apparatus for 3 to 4 h. (water removed azeotropically) Reaction mass is cooled to 25 to 30° C. Obtained solid is filtered off and washed by toluene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09394292B2 |
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| Source dataset | uspto-grants-2016_07 |
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| ORD ID | ord-82ac11430a634f398acc8cc312020e87 |
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| Source note | uspto-grants-2016_07 |
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