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HRID1054149

反应详情

EQUATION

反应方程式

HRID 1054149 的结构方程式

REACTANTS

反应物

2
结构：O=CO
HCID284

Formic acid

CH2O2

结构：NC[C@H]1CN(c2ccc(N3CCOCC3=O)cc2)C(=O)O1
HCID11346837

4-{4-[(5S)-5-(Aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one

C14H17N3O4

PRODUCTS

生成物

1
结构：O=CNC[C@H]1CN(c2ccc(N3CCOCC3=O)cc2)C(=O)O1
HCID90258317

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

CONDITIONS

反应条件

温度
115 °C

PROCEDURE

实验过程

In a four neck round bottom flask charged 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one free base (50 g) ether (450 ml) and formic acid (21.63 g). Reaction mass then heated azeotropically to 110-120° C. employing dean-stark apparatus for 3 to 4 h. (water removed azeotropically) Reaction mass is cooled to 25 to 30° C. Obtained solid is filtered off and washed by toluene.

WORKUP

后处理

  1. customReaction mass
  2. customfor 3 to 4 h.
  3. customremoved azeotropically)
  4. customReaction mass
  5. temperatureis cooled to 25 to 30° C
  6. customObtained solid
  7. filtrationis filtered off
  8. washwashed by toluene