Acetic Acid → Rivaroxaban

Participants

Reaction Conditions

Reaction Steps

5-chloro-N-formyl-N-({(5 S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide (1.0 g) taken in mixture of acetic acid (5 ml) and conc hydrochloric acid (0.25 ml). Obtained reaction mixture is heated to 70 to 80° C. for 3 to 4 h. After completion of reaction, cooled reaction mixture 25 to 30° C. and added methanol (5 ml). The precipitated solid is filtered off and washed by methanol (3 ml).

Provenance & Evidence