反应详情

N-({(5 S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)formamide (1 g) taken in a dichloromethane(10 ml) and stirred reaction mass at 25 to 30° C. for 30 minutes. To this mixture added solution of 4-nitrophenyl-5-chlorothiophene-2-carboxylate (1.06 g) in a dichloromethane (10 ml) and sodium hydroxide (0.38 g) in water (5 ml) simultaneously through addition funnel. Obtained reaction mass then stirred for 1 to 2 h at 25 to 30° C. After completion of reaction, Separated organic layer and concentrated under reduced pressure to obtain residue. Added acetic acid and methanol to residue stirred for 30 minutes and obtained solid is filtered off. Washed solid with methanol.

1. customreaction mass at 25 to 30° C. for 30 minutes
2. additionsimultaneously through addition funnel
3. customObtained
4. customreaction mass
5. stirringthen stirred for 1 to 2 h at 25 to 30° C
6. customAfter completion of reaction
7. customSeparated organic layer
8. concentrationconcentrated under reduced pressure
9. customto obtain residue
10. customobtained solid
11. filtrationis filtered off
12. washWashed solid with methanol