p-Toluenesulfonic acid → HCID 89691331, compound

Participants

Reaction Steps

To a solution of product (6-A) (2.2 g, 5.56 mmol) in acetone (20 ml) was added TsOH (191 mg, 1.11 mmol), and the solution was stirred at ambient temperature for 3 h. The reaction was quenched by saturated NaHCO3 (20 mL) and extracted with ethyl acetate (50 mL×2). The combined organic layers were washed with brine (50 mL), dried over Na2SO4, and concentrated and purified by CC (DCM:MeOH=300:1 to 100:1) to give product (7-A) (1.8 g, 92%) as a brown solid. LC-MS (M+H)+=352.

Provenance & Evidence