2-(Chloromethyl)benzothiazole → Ethyl 2-((benzo[d]thiazol-2-ylmethoxy)amino)benzoate

HRID 1054222Notes

Reaction equation

HRID 1054222 reaction equation
[OH:1][NH:2][C:3]1[CH:13]=[CH:12][CH:11]=[CH:10][C:4]=1[C:5]([O:7][CH2:8][CH3:9])=[O:6].Cl[CH2:15][C:16]1[S:17][C:18]2[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=2[N:20]=1>>[S:17]1[C:18]2[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=2[N:20]=[C:16]1[CH2:15][O:1][NH:2][C:3]1[CH:13]=[CH:12][CH:11]=[CH:10][C:4]=1[C:5]([O:7][CH2:8][CH3:9])=[O:6]

Participants

3

Reactant 2

HCID 3049782-(Chloromethyl)benzothiazoleHCID 13571167Ethyl 2-(hydroxyamino)benzoate

Product 1

HCID 118451773Ethyl 2-((benzo[d]thiazol-2-ylmethoxy)amino)benzoateYield 52%

Procedure

The titled compound was prepared using similar procedure as that of Example-1 (step-2) using ethyl 2-(hydroxyamino)benzoate and 2-(chloromethyl)benzo[d]thiazole in 52% yield.

Sources & evidence

ORD record
ord-35ad7c65fe49444384d1bd77a8982cfd
Source dataset
uspto-grants-2016_07
Patent number
US09394300B2

Reaction notes

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