HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → HCID 16641709, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | HCID 58994987 | HCID 58994987 | — |
| Catalyst | Zirconium chloride (ZrCl4), (T-4)- | HCID 9856075 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 16641709 | HCID 16641709 | — |
Reaction Steps
A solution of 4-(4-nitro-phenyl)-tetrahydro-pyran-4-carbonitrile (as prepared in the previous step) in THF is treated with ZrCl4 and NaBH4 (Synthesis, (12), 995-6 (1988)) at RT. The mixture is diluted with EtOAc and washed with water. The organic layer is dried (MgSO4) and concentrated in vacuo. The residue is purified by silica gel chromatography with the appropriate solvent to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09394289B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-07080e059359423f8cb288b3ec441c6d |
| Source note | uspto-grants-2016_07 |