HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 58994992, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 4-(4-Nitro-phenyl)-1,1-dioxo-hexahydro-1lambda6-thiopyran-4-carbonitrile | HCID 58994932 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 58994992 | HCID 58994992 | — |
Reaction Steps
A solution of 4-(4-nitro-phenyl)-1,1-dioxo-hexahydro-1λ6-thiopyran-4-carbonitrile (as prepared in the previous step) in ethanol and water is treated with NaBO3 (Synthetic Communications, 20(4), 563-71, (1990)). The mixture is diluted with EtOAc and washed with water. The organic layer is dried (MgSO4) and concentrated in vacuo. The residue is purified by silica gel chromatography with the appropriate solvent to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09394289B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-e7058be0381444c3b983310c1caf07f3 |
| Source note | uspto-grants-2016_07 |