Lithium Hydroxide → HCID 118590363, compound

Participants

Reaction Steps

To a stirred solution of (S)-ethyl 2-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamido)acetate (Example-18; Isomer-II) (0.08 g, 0.18 mmol) in ethanol (10 mL) was added 1M LiOH solution at 20° C. then stirred for 1 h RT. After completion of reaction solvent was remove under reduced pressure then residue was dissolved in water and washed with diethylether and water layer was acidified with 2N HCl (pH˜2) and solid was filter to afford pure (S)-2-(6(2(2,5difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-a]pyridine-3-carboxamido)acetic acid (Isomer-II) (0.035 g, 47.29% Yield). MS (ESI): m/z 401.3 (M+H); 1H NMR (300 MHz, DMSO-d6) δ 12.66-12.60 (1H, bs), 8.75-8.72 (2H, m), 8.27 (1H, s), 7.59-7.55 (1H, d J=12 Hz), 7.35-7.28 (1H, m), 7.16-7.10 (1H, m), 7.00-6.93 (2H, m), 5.00-4.98 (1H, d J=6 Hz), 3.93-3.91 (2H, d J=6 Hz), 3.79-3.74 (1H, m), 2.03-1.87 (3H, m) ppm.

Provenance & Evidence