HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 4-iodo-7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Chloromethyl 2-(trimethylsilyl)ethyl ether | HCID 2724271 | — |
| Reactant | 4-Iodo-7H-pyrrolo(2,3-d)pyrimidine | HCID 57870804 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-iodo-7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidine | HCID 57870803 | — |
Reaction Steps
610 mg (2.49 mmol) of 4-iodo-7H-pyrrolo[2,3-d]pyrimidine was dissolved in 2.5 mL DMF. 110 mg (2.74 mmol) of 60% sodium hydride was added followed by 480 μL (2.74 mmol) of trimethylsilylethoxymethyl chloride. Yield: 750 mg of an oily product, 90% pure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09394307B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-a465c4a0d6cd499f9eb8ba3bf41eef61 |
| Source note | uspto-grants-2016_07 |