Thionyl Chloride → HCID 178440685, compound

Participants

Reaction Steps

A solution of 4-(5-tert-Butyl-1H-benzoimidazol-2-yl)-butan-1-ol (1.00 g, 4.06 mmol) in thionyl chloride (10 ml) was heated to 80° for 1 h. LCMS analysis shows complete consumption of starting material. The solvent was evaporated and the residue was co-evaporated with toluene (4×10 ml) to afford 1.22 g (100%) of crude product as a beige solid which was used without purification; MS (ESI+) for C15H21ClN2 m/z 1 [M+H]+, 265.15; HPLC purity 99% (ret. time, 1.66 min).

Provenance & Evidence