Hydrochloric Acid → HCID 86705761, compound

Participants

Reaction Steps

7-[(3aS,4R,6R,6aR)-2,2-dimethyl-6-{[methyl({4-[6-(trifluoromethyl)-1-[2-(trimethylsilyl)ethoxy]-1H-1,3-benzodiazol-2-yl]butyl})amino]methyl}-hexahydrocyclopenta[d][1,3]dioxol-4-yl]-N-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (103.7 mg, 0.14 mmol) in conc. HCl solution (2 ml, 21.54 mmol) and methanol (2 ml) was heated to 40° C. for 4 h. The reaction mixture was concentrated under reduced pressure, and the residue partitioned between sat. NaHCO3(aq) (10 ml) and EtOAc (10 ml). A small amount of MeOH (−1 ml) was added to aid dissolution, and the layers were separated. The aqueous layer was extracted with EtOAc (2×10 ml), the combined organics were then dried (MgSO4) and concentrated to afford 32.2 mg (40.5%) of the title compound.

Provenance & Evidence