Hydrochloric Acid → HCID 178505097, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 12M HCl(aq) in MeOH (1:1, 5 ml) was added to N-{[(3aR,4R,6R,6aS)-6-[4-(cyclopropylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-2,2-dimethyl-hexahydrocyclopenta[d][1,3]dioxol-4-yl]methyl}-N-{4-[6-chloro-5-(trifluoromethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-1,3-benzodiazol-2-yl]butyl}methanesulfonamide (155 mg, 0.19 mmol) and stirred at 40° C. for 4 hours. The reaction mixture was concentrated in vacuo. The residue was dissolved in EtOAc (150 ml), washed with sat. NaHCO3 (2×50 ml), dried over Na2SO4, filtered and evaporated. Purification by silica gel column chromatography, eluting with 7N NH3 in MeOH:DCM (5:95-1:9) gave the desired product as an oil.

Provenance & Evidence