HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 3-(4-Bromophenoxy)azetidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl 3-(4-bromophenoxy)azetidine-1-carboxylate | HCID 68605010 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-(4-Bromophenoxy)azetidine | HCID 24902358 | 100.8% |
Reaction Steps
To a solution of tert-butyl 3-(4-bromophenoxy)azetidine-1-carboxylate (300 mg, 0.90 mmol) in CH2Cl2 (5 mL) was added TFA (5 mL). The mixture was stirred at room temperature overnight. The reaction mixture was concentrated in vacuo to give 3-(4-bromophenoxy)azetidine (207 mg, 100%) as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09394285B2 |
| Source dataset | uspto-grants-2016_07 |
| ORD ID | ord-0b6157004e0647808e5ed268b9b7c8ed |
| Source note | uspto-grants-2016_07 |