Triethylamine → 2-(4-Bromophenyl)-1-(methylsulfonyl)azetidine

Participants

Reaction Steps

To a mixture of 2-(4-bromophenyl)azetidine (200 mg, 0.808 mmol) and triethylamine (98 mg, 0.97 mmol) in anhydrous dichloromethane (6 mL) was added methanesulfonyl chloride (111 mg, 0.97 mmol). The mixture was stirred at rt for 5 hours. The mixture was poured into ethyl acetate and washed with water. The organic phase was dried over sodium sulfate, filtered, concentrated in vacuo to give the title compound (200 mg, 85% yield) as a yellow oil. 1H NMR (400 MHz, CDCl3): δ7.50 (d, 2 H), 7.25 (d, 2 H), 5.30-5.20 (m, 1 H), 420-4.00 (m, 2 H), 3.63 (s, 3 H), 2.70 (m, 1 H), 2.15 (m, 1 H).

Provenance & Evidence