反应详情

温度

70 °C

To a solution of methyl 6-chloro-5-(4-{[(1S,2S)-2-hydroxycyclohexyl]oxy}phenyl)-1H-indole-3-carboxylate (80 mg, 0.22 mmol) in methanol (8 mL) was added aq. 1.0M NaOH (2.0 mL, 2.0 mmol). The mixture was stirred at 70° C. for 24 hours. The mixture was adjusted to pH 7 and purified by reverse phase HPLC to give the title compound (12.6 mg, 16% yield) as a white solid. MS (ES+) 408.2 (M+Na)+. 1H NMR (400 MHz, DMSO-d6): δ 12.40-11.90 (br. s, 1 H), 11.85 (s, 1 H), 8.10 (s, 1 H), 7.90 (s, 1 H), 7.61 (m, 1 H), 7.32 (d, 2 H), 7.00 (d, 2 H), 4.93 (m, 1 H), 4.10 (m, 1 H), 3.57 (m, 1 H), 2.05 (m, 1 H), 1.88 (m, 1 H), 1.53 (m, 2 H), 1.40-1.10 (m, 4 H).

1. custompurified by reverse phase HPLC